Description

Sulf-DBCO-NHS Ester is a heterobifunctional crosslinking reagent featuring a sulfonated dibenzocyclooctyne (DBCO) group and an N-hydroxysuccinimide (NHS) ester. This compound is engineered for efficient, copper-free click chemistry conjugation, enabling the stable labeling of biomolecules under mild, aqueous conditions. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs) and diagnostic assays.

Application

• Copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for bioconjugation.
• Site-specific labeling of proteins, antibodies, and peptides containing azide functional groups.
• Development and synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Surface functionalization of nanoparticles, polymers, and solid supports for biosensor development.
• Preparation of fluorescent or affinity probes for cellular imaging and proteomics studies.
• Modification of oligonucleotides and other biomolecules for diagnostic assay kits.
• Materials science applications requiring bio-orthogonal chemistry for hydrogel formation or polymer crosslinking.

Basic Information

Product Name	Sulf-DBCO-NHS Ester
CAS No.	1379761-19-9
Molecular Formula	C₂₄H₂₀N₂O₈S
Molecular Weight	496.49 g/mol
Synonyms	DBCO-Sulfo-NHS Ester; Sulfo-DBCO-NHS Ester; 6-((6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)amino)-6-oxohexyl 3-(3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate; Sulfonated Dibenzocyclooctyne NHS Ester; SULFO-DBCO®-NHS Ester (trade name variant); Azadibenzocyclooctyne Sulfo-NHS Ester; SDBCO-NHS
EINECS	Contact for details

Quality Control

Our Sulf-DBCO-NHS Ester is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.