Description

3,4-Difluoro-5-Hydroxyphenylboronic Acid is a highly functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both boronic acid and phenolic hydroxyl groups on a difluorinated aromatic ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of novel polymers, sensors, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential reagent for forming carbon-carbon bonds in the synthesis of complex, biaryl structures common in many advanced chemical products.
• Ligand and Catalyst Development: Utilized in the creation of novel ligands for transition metal catalysis and in organoboron chemistry research.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	3,4-Difluoro-5-Hydroxyphenylboronic Acid
CAS No.	1379466-84-8
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	(3,4-Difluoro-5-hydroxyphenyl)boronic acid; 5-Borono-2,3-difluorophenol; 2,3-Difluoro-5-hydroxybenzeneboronic acid; 3,4-Difluoro-5-hydroxybenzeneboronic acid; Boronic acid, B-(3,4-difluoro-5-hydroxyphenyl)-; 1379466-84-8
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.