Description

Pomalidomide-D5 is a deuterated analog of the immunomodulatory drug Pomalidomide, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Pomalidomide in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound for the accurate and reliable quantification of Pomalidomide in plasma, serum, and tissue samples via mass spectrometry.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used to investigate metabolic pathways and identify metabolites, aiding in the understanding of drug efficacy and safety profiles.
• Method Development and Validation: Essential for developing, optimizing, and validating robust LC-MS/MS methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control and Assurance: Supports analytical QC in pharmaceutical manufacturing to ensure batch consistency and purity of the active pharmaceutical ingredient (API).

Basic Information

Product Name	Pomalidomide-D5
CAS No.	1377838-49-7
Molecular Formula	C13H6D5N3O4
Molecular Weight	278.26 g/mol
Synonyms	4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione-d5; (RS)-3-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione-d5; CC-4047-d5; Actimid-d5; Pomalyst-d5; Deuterated Pomalidomide; Pomalidomide (phenyl-d5)
EINECS	Contact for details

Quality Control

Our Pomalidomide-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant industry standards for reference materials to ensure data integrity and reproducibility in your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.