Description

(E)-2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS NO 1377220-06-8 is a high-purity, advanced pharmaceutical intermediate and a key building block in modern synthetic chemistry. This compound is valued for its role as a versatile boronic ester derivative, enabling critical carbon-carbon bond formation reactions. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex organic molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for constructing biaryl and conjugated systems in drug discovery and material science.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a difluorostyryl motif.
• Agrochemical Synthesis: Serves as a key precursor in developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Organic Light-Emitting Diodes (OLEDs): A building block for creating advanced organic semiconductors and emissive layer materials.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis.
• Academic and Industrial R&D: Essential for methodological studies and the development of new synthetic pathways in organic chemistry.

Basic Information

Product Name	(E)-2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	1377220-06-8
Molecular Formula	C16H21BF2O2
Molecular Weight	294.15 g/mol
Synonyms	(E)-2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,6-Difluoro-β-styrylboronic acid pinacol ester; (E)-2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-4,4,5,5-Tetramethyl-2-(2,6-difluorostyryl)-1,3,2-dioxaborolane; 2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-2-(2,6-Difluorovinyl)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (E)-2-(2,6-difluorostyryl)boronate; 1377220-06-8
EINECS	Contact for details

Quality Control

Our (E)-2-(2,6-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.