Description

2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1377152-43-6 is a high-value, fluorinated styryl boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to introduce fluorinated aromatic motifs into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for drug discovery, crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated aromatic rings, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorostyryl moiety enhances biological activity and environmental persistence.
• Material Science Research: Building block for creating fluorinated organic semiconductors, liquid crystals, and polymers for OLEDs and other electronic applications.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed C-C bond formation, allowing for the modular construction of complex, biaryl structures under mild conditions.
• Chemical Biology Probes: Utilized in the development of fluorescent tags and molecular probes for imaging and diagnostic applications.
• Academic & R&D Laboratories: Serves as a specialized reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Item	Details
Product Name	2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1377152-43-6
Molecular Formula	C14H18BFO2
Molecular Weight	248.10 g/mol
Synonyms	2-(2-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Fluorostyryl)boronic acid pinacol ester; 2-(2-Fluorovinyl)phenylboronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-[2-(2-fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-; 2-Fluoro-β-styrylboronic acid pinacol ester; (E)-2-(2-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Fluorostyryl)BPin; 2-Fluorostyrylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.