Description

2-Fluoro-4-Hydroxyphenylboronic Acid is a high-purity boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functional groups, enabling precise cross-coupling reactions essential for constructing complex molecular architectures. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine and hydroxyl substituents impart specific biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, due to its ability to form stable boronate esters.
• Chemical Biology Probes: Serves as a handle for bioconjugation and the development of sensors or affinity purification tags.
• Ligand for Catalysis: Can be utilized to create novel ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Fluoro-4-Hydroxyphenylboronic Acid
CAS No.	1376989-43-3
Molecular Formula	C6H6BFO3
Molecular Weight	155.93 g/mol
Synonyms	(2-Fluoro-4-hydroxyphenyl)boronic acid; 4-Hydroxy-2-fluorobenzeneboronic acid; 2-Fluoro-4-hydroxybenzeneboronic acid; B-(2-Fluoro-4-hydroxyphenyl)boronic acid; 2-Fluoro-4-hydroxy phenyl boronic acid; 2-Fluoro-4-hydroxybenzeneboronic acid pinacol ester (common protected form); 1376989-43-3
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.