Description

p-Salicylic Acid 4-Glucuronide Potassium Salt is a high-purity reference standard and metabolite of salicylic acid, a key compound in pharmaceutical research and development. Its primary value lies in its critical role as a biomarker for pharmacokinetic studies and metabolic pathway analysis, ensuring accurate quantification in biological matrices. This compound is essential for analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug metabolism and safety evaluation studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration and validation of analytical methods, particularly HPLC and LC-MS/MS, in bioanalytical laboratories.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a critical metabolite standard for studying the biotransformation, clearance, and exposure levels of salicylate-based drugs and prodrugs.
• Biomarker Analysis: Employed in clinical and preclinical studies to accurately measure salicylic acid glucuronidation, a major Phase II detoxification pathway, for toxicology and efficacy assessments.
• Enzyme Activity Assays: Utilized in vitro to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes responsible for glucuronidation reactions.
• Diagnostic Kit Development: Acts a key component in the development of diagnostic assays and kits designed to monitor drug levels or metabolic disorders related to salicylate metabolism.

Basic Information

Product Name	p-Salicylic Acid 4-Glucuronide Potassium Salt
CAS No.	1376574-47-8
Molecular Formula	C13H13KO9
Molecular Weight	352.34 g/mol
Synonyms	Salicylic Acid 4-O-β-D-Glucuronide Potassium Salt; 4-Glucuronylsalicylic Acid Potassium Salt; p-Hydroxybenzoyl Glucuronide Potassium Salt; Salicyluric Acid Glucuronide Potassium Salt (related metabolite); SA-4-G Potassium; Potassium (2S,3S,4S,5R,6S)-6-((4-hydroxy-2-carboxybenzoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of p-Salicylic Acid 4-Glucuronide Potassium Salt is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the high-purity standards required for reference materials. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles, is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.