Description

cis-3-Hydroxy-Apatinib-o-Glucuronide is a key glucuronide metabolite of the tyrosine kinase inhibitor Apatinib, representing a critical compound for pharmaceutical research and development. This metabolite is essential for understanding the drug's metabolic pathway, pharmacokinetics, and potential for drug-drug interactions. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Reference Standard for Bioanalysis: Used as a certified standard for the quantitative and qualitative analysis of Apatinib metabolites in biological matrices (plasma, urine) via LC-MS/MS or HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to elucidate the metabolic fate, clearance mechanisms, and exposure levels of Apatinib.
• Impurity Identification and Control: Serves as an identified impurity reference standard to monitor and control quality during Apatinib active pharmaceutical ingredient (API) manufacturing, supporting regulatory filings.
• Pharmacological Research: Employed in studies to assess the activity, toxicity, or role of glucuronidated metabolites in the overall efficacy and safety profile of Apatinib.
• Clinical Study Support: Used in the development and validation of assays for therapeutic drug monitoring (TDM) and clinical pharmacokinetic trials.

Basic Information

Product Name	cis-3-Hydroxy-Apatinib-o-Glucuronide
CAS No.	1376331-61-1
Molecular Formula	C30H31N3O9
Molecular Weight	577.58 g/mol
Synonyms	Apatinib 3-O-Glucuronide; Apatinib Glucuronide Metabolite; 3-Hydroxy Apatinib Glucuronide; cis-3-Hydroxy Apatinib O-Glucuronide; N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide 3-O-Glucuronide; YN968D1 Glucuronide; Rivoceranib Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our cis-3-Hydroxy-Apatinib-o-Glucuronide is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC purity analysis and structural confirmation by mass spectrometry (MS) and NMR. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The material should be handled in a controlled environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.