Description

2-Cyano-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the cyano and trifluoromethyl substituents impart unique electronic and steric properties to the resulting molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting CNS disorders, inflammation, and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the structural motif to improve efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, where its aromatic core and substituents fine-tune electronic properties.
• Chemical Biology Probes: Utilized in the construction of molecular probes and sensors for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Cyano-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1375110-43-2
Molecular Formula	C8H5BF3NO2
Molecular Weight	214.94 g/mol
Synonyms	[2-Cyano-5-(trifluoromethyl)phenyl]boronic acid; (2-Cyano-5-(trifluoromethyl)phenyl)boronic acid; 2-Cyanophenyl-5-trifluoromethylboronic acid; 5-Trifluoromethyl-2-cyanophenylboronic acid; Boronic acid, B-[2-cyano-5-(trifluoromethyl)phenyl]-; 2-CN-5-CF3-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-5-(Trifluoromethyl)Phenylboronic Acid is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and mass spectrometry to ensure identity, purity, and consistency. Our products are suitable for use under cGMP conditions for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.