Description

2-Bromo-1-Ethoxy-3-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique halogenated and alkoxy-substituted benzene structure, which enables precise molecular modifications. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials due to its electron-withdrawing and steric properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Bromo-1-Ethoxy-3-Fluorobenzene
CAS No.	1375098-48-8
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-Bromo-2-Ethoxy-3-Fluorobenzene; 3-Fluoro-2-Bromophenetole; 2-Bromo-3-Fluorophenetole; 2-Bromo-1-Ethoxy-3-Fluorobenzene; 2-Bromo-3-fluoro-1-ethoxybenzene; 1-Ethoxy-2-bromo-3-fluorobenzene; Benzene, 2-bromo-1-ethoxy-3-fluoro-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Ethoxy-3-Fluorobenzene is manufactured and tested under strict quality management systems. We ensure compliance with rigorous internal specifications, which typically include identity confirmation, purity assay, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.