Description

{4-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Phenyl}Acetic Acid is a high-value fluorinated aromatic building block, also known by its CAS number 1375068-91-9. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals due to its unique trifluoromethyl and fluoro-substituted biphenyl core. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms contribute to lipophilicity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its rigid, fluorinated aromatic structure.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	{4-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Phenyl}Acetic Acid
CAS No.	1375068-91-9
Molecular Formula	C15H10F4O2
Molecular Weight	298.24 g/mol
Synonyms	[4-[4-Fluoro-3-(trifluoromethyl)phenyl]phenyl]acetic acid; 2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]phenyl}acetic acid; 4'-(Fluoro-3'-trifluoromethylphenyl)phenylacetic acid; 4-(4-Fluoro-3-trifluoromethylphenyl)phenylacetic acid; 1375068-91-9; FTFMPPA (abbreviation); Biphenyl-4-acetic acid, 4'-fluoro-3'-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our {4-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Phenyl}Acetic Acid is manufactured under strict quality management systems. We provide material with typical purities of ≥97% (HPLC) for research and ≥99% for advanced pharmaceutical applications, supported by comprehensive Certificates of Analysis (COA). Our quality commitment ensures batch-to-batch consistency, traceability, and compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Research Grade) ≥99.0% (Pharma Grade)
Related Substances (HPLC)	Total impurities ≤3.0% Any single unknown impurity ≤1.0%
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.