Description

Fmoc-D-2-Amino-4-(Ethyl(Thio))Butyric Acid is a high-purity, non-proteinogenic amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a thioether-functionalized side chain into peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and the creation of novel peptide-based therapeutics and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: For developing peptide drug candidates with modified properties, such as enhanced stability or targeted delivery.
• Bioconjugation Chemistry: The thioether side chain serves as a handle for site-specific labeling or attachment to other molecules (e.g., polymers, dyes, or drug payloads).
• Structure-Activity Relationship (SAR) Studies: Used to investigate the role of specific amino acid modifications on peptide function and receptor binding.
• Production of Peptide Libraries: For high-throughput screening in drug discovery to identify new bioactive compounds.
• Academic & Industrial R&D: Fundamental research in biochemistry, chemical biology, and material science involving peptide design.

Basic Information

Product Name	Fmoc-D-2-Amino-4-(Ethyl(Thio))Butyric Acid
CAS No.	1374669-68-7
Molecular Formula	C22H25NO4S
Molecular Weight	399.50 g/mol
Synonyms	Fmoc-D-Abu(S-Et) OH; Fmoc-D-2-Amino-4-(ethylthio)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homocysteine ethyl thioether; Fmoc-D-Hcy(S-Et); N-α-Fmoc-D-2-amino-4-(ethylthio)butyric acid; Fmoc-D-2-amino-4-(ethylsulfanyl)butanoic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(ethylthio)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-2-Amino-4-(Ethyl(Thio))Butyric Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to industry best practices suitable for GMP-aligned pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.