Description

1-(Hydroxymethyl)Cyclobutanecarbonitrile is a versatile bifunctional organic building block featuring both a reactive nitrile group and a hydroxymethyl substituent on a cyclobutane ring. This unique structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought by R&D chemists and process development scientists in the life sciences and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for constructing constrained ring systems.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides where the cyclobutane scaffold imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Fine Chemical Production: An important building block for manufacturing complex dyes, flavors, and fragrances.

Basic Information

Product Name	1-(Hydroxymethyl)Cyclobutanecarbonitrile
CAS No.	1374657-44-9
Molecular Formula	C6H9NO
Molecular Weight	111.14 g/mol
Synonyms	(Hydroxymethyl)cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(hydroxymethyl)-; 1-(Hydroxymethyl)cyclobutanecarbonitrile; 1-Cyclobutanecarbonitrile-1-methanol; (1-Cyanocyclobutyl)methanol
EINECS	Contact for details

Quality Control

Our 1-(Hydroxymethyl)Cyclobutanecarbonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.