Description

tert-Butyl 3-(Aminomethyl)-3-Cyanoazetidine-1-Carboxylate is a high-value, multifunctional azetidine derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both protected amine and nitrile functionalities on a strained four-membered ring, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including protease inhibitors and other biologically relevant small molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents with novel modes of action.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein functions.
• Peptidomimetic Chemistry: The azetidine core is utilized to create conformationally constrained peptide analogs with enhanced metabolic stability.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique thermal or mechanical properties.
• Ligand Synthesis for Catalysis: The aminomethyl and nitrile groups provide handles for constructing sophisticated chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)-3-Cyanoazetidine-1-Carboxylate
CAS No.	1374653-62-9
Molecular Formula	C10H17N3O2
Molecular Weight	211.26 g/mol
Synonyms	1-Boc-3-(Aminomethyl)-3-cyanoazetidine; 3-(Aminomethyl)-3-cyanoazetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-cyano-3-(aminomethyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(aminomethyl)-3-cyanoazetidine; 3-Cyano-3-(aminomethyl)azetidine-1-carboxylic acid tert-butyl ester; Boc-3-(Aminomethyl)-3-cyanoazetidine; Azetidine-1-carboxylic acid, 3-(aminomethyl)-3-cyano-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Aminomethyl)-3-Cyanoazetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.