Description

4-Difluorophenyl)Acetic Acid Hydrochloride is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluorophenyl moiety is prized for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorination enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP conditions.
• Academic and Industrial R&D: Fundamental reagent for methodological development and exploring new fluorination chemistry in research laboratories.

Basic Information

Item	Detail
Product Name	4-Difluorophenyl)Acetic Acid Hydrochloride
CAS No.	1374651-47-4
Molecular Formula	C8H7F2O2 • HCl
Molecular Weight	208.60 g/mol (Free acid) / 245.06 g/mol (HCl salt)
Synonyms	(4-Difluorophenyl)acetic acid hydrochloride; 2-(4-Difluorophenyl)acetic acid hydrochloride; 4-Difluorobenzeneacetic acid hydrochloride; p-Difluorophenylacetic acid HCl; α-(4-Difluorophenyl)acetic acid hydrochloride; 1374651-47-4; (4-Difluorophenyl)ethanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Difluorophenyl)Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.