Description

4-((tert-Butoxycarbonylamino)Methyl)-3-Fluorophenylboronic Acid is a sophisticated bifunctional building block that integrates a boronic acid moiety with a protected amine group. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions while offering orthogonal protection for subsequent synthetic elaboration. It is primarily required by pharmaceutical and advanced materials researchers for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing biaryl and heterobiaryl scaffolds common in kinase inhibitors and other therapeutic agents.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds with aryl or vinyl halides, enabling the construction of complex molecular architectures.
• Protected Amine Synthon: The tert-butoxycarbonyl (Boc) protected amino methyl group allows for selective deprotection and further functionalization, making it valuable in peptide mimetics and linker chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require fluorinated aromatic components for enhanced bioactivity and stability.
• Material Science: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where precise fluorine and boron incorporation modulates electronic and structural properties.
• Chemical Biology & Probe Development: Useful for creating fluorescent probes, affinity tags, and other tools where the boronic acid can act as a sensor or recognition element for diols.

Basic Information

Product Name	4-((tert-Butoxycarbonylamino)Methyl)-3-Fluorophenylboronic Acid
CAS No.	1374451-80-5
Molecular Formula	C₁₃H₁₉BFNO₄
Molecular Weight	283.11 g/mol
Synonyms	3-Fluoro-4-((((2-methylpropan-2-yl)oxy)carbonylamino)methyl)benzeneboronic acid; 4-(Boc-aminomethyl)-3-fluorophenylboronic acid; 3-Fluoro-4-(N-Boc-aminomethyl)phenylboronic acid; 4-(N-Boc-aminomethyl)-3-fluorobenzeneboronic acid; (3-Fluoro-4-((((tert-butoxy)carbonyl)amino)methyl)phenyl)boronic acid; BOC-AMBA-F; N-Boc-4-borono-2-fluorobenzylamine
EINECS	Contact for details

Quality Control

Our 4-((tert-Butoxycarbonylamino)Methyl)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your research and development, ensuring compliance with internal and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.