Description

6-Chloro-2,3-Difluoroanisole, 97% is a high-purity fluorinated anisole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen substituents, which enable precise functionalization for creating complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its impact on molecular polarity and mesophase behavior.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: A versatile reagent for method development, exploring new fluorination techniques, and synthesizing complex aromatic ethers in academic and industrial R&D labs.

Basic Information

Item	Detail
Product Name	6-Chloro-2,3-Difluoroanisole, 97%
CAS No.	1373921-04-0
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-methoxybenzene; 2,3-Difluoro-6-chloroanisole; 4-Chloro-2,3-difluoroanisole; 2,3-Difluoro-4-methoxychlorobenzene; Anisole, 6-chloro-2,3-difluoro-; 6-Chloro-2,3-difluoromethoxybenzene; Benzene, 1-chloro-2,3-difluoro-4-methoxy-
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2,3-Difluoroanisole is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the specified 97% purity and is suitable for your sensitive synthesis workflows. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for each lot upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.