Description

1-(Chloromethyl)-2-Fluoro-3-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials that require the introduction of a versatile chloromethyl and trifluoromethoxy-substituted benzene scaffold.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Employed to introduce functional aromatic groups into polymer chains, modifying thermal stability, chemical resistance, and other material properties.
• Cross-Coupling Reactions: The chloromethyl group acts as a handle for further functionalization via palladium-catalyzed or other metal-mediated coupling reactions.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	1-(Chloromethyl)-2-Fluoro-3-(Trifluoromethoxy)Benzene
CAS No.	1373864-66-4
Molecular Formula	C9H5ClF4O
Molecular Weight	240.58 g/mol
Synonyms	2-Fluoro-α-(chloromethyl)-3-(trifluoromethoxy)benzene; 1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene; Benzene, 1-(chloromethyl)-2-fluoro-3-(trifluoromethoxy)-; α-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene; 2-Fluoro-3-(trifluoromethoxy)benzyl chloride
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-2-Fluoro-3-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to the light-sensitive nature and reactivity of the chloromethyl group, containers should be kept sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.