Description

Boc-(S)-α-(3-Phenyallyl)-Proline is a protected, non-proteinogenic amino acid derivative of significant value in advanced organic synthesis. This chiral building block is essential for the construction of complex peptide mimetics and peptidomimetic drug candidates, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in protease inhibitor design.
• Peptidomimetic Synthesis: Used to incorporate constrained proline analogs into peptide chains to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile building block for creating focused libraries of compounds for structure-activity relationship (SAR) studies.
• Bioconjugation: Can be employed in the synthesis of peptide-based probes and conjugates for diagnostic or targeted delivery applications.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chiral centers with high enantiomeric purity.

Basic Information

Product Name	Boc-(S)-α-(3-Phenyallyl)-Proline
CAS No.	1373512-24-3
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	(S)-1-((tert-Butoxycarbonyl)-2-(3-phenylallyl)pyrrolidine-2-carboxylic acid; Boc-L-α-(3-Phenyallyl)proline; tert-Butyl (2S)-2-(3-phenylprop-2-en-1-yl)-1,2-pyrrolidinedicarboxylate; N-Boc-3-(3-phenylallyl)-L-proline; (S)-1-Boc-2-(3-phenylallyl)proline; (S)-2-(3-Phenylallyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(3-Phenyallyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.