Description

2-(3,3-Difluorocyclobutyl)Acetic Acid CAS NO 1373503-48-0 is a high-value fluorinated cyclobutane derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring a difluorocyclobutyl moiety attached to an acetic acid group, makes it an essential intermediate for introducing conformational rigidity and lipophilicity into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its properties can enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinases, GPCRs, and other biological targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluorocyclobutyl group can improve environmental stability and efficacy.
• Material Science Precursor: Employed in the synthesis of specialized polymers and advanced materials that require fluorinated components for specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Serves as a backbone for constructing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the effects of gem-difluorination on cyclobutane rings in various chemical contexts.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)Acetic Acid
CAS No.	1373503-48-0
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	2-(3,3-Difluorocyclobutyl)ethanoic acid; Acetic acid, 2-(3,3-difluorocyclobutyl)-; 3,3-Difluorocyclobutaneacetic acid; (3,3-Difluorocyclobutyl)acetic acid; 2-(3,3-Difluorocyclobutyl)acetic acid; 1373503-48-0; Difluorocyclobutylacetic acid; Cyclobutaneacetic acid, 3,3-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-(3,3-Difluorocyclobutyl)Acetic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.