Description

tert-Butyl 5-(Aminomethyl)-3,3-difluoropiperidine-1-carboxylate is a high-purity, protected piperidine derivative featuring both a Boc-protected amine and a primary aminomethyl group, making it a versatile and valuable building block in advanced organic synthesis. Its core value lies in enabling the efficient construction of complex molecules, particularly for pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in drug discovery, especially for creating novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Protease Inhibitor Scaffold: Used in the research and development of protease inhibitors, leveraging the difluoropiperidine motif for enhanced metabolic stability and binding affinity.
• Building Block for Peptidomimetics: Serves as a constrained amino acid analog for creating novel peptidomimetic libraries in medicinal chemistry programs.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and chemical biology applications.
• Agrochemical Research: Utilized as an intermediate in the development of new crop protection agents with improved efficacy.
• Chemical Biology Probes: Acts as a core structure for developing fluorescent or affinity tags to study biological processes.

Basic Information

Product Name	tert-Butyl 5-(Aminomethyl)-3,3-difluoropiperidine-1-carboxylate
CAS No.	1373502-92-1
Molecular Formula	C11H20F2N2O2
Molecular Weight	250.29 g/mol
Synonyms	1-Boc-5-(aminomethyl)-3,3-difluoropiperidine; 5-(Aminomethyl)-3,3-difluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate; 3,3-Difluoro-5-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-5-(aminomethyl)-3,3-difluoropiperidine; Boc-5-(aminomethyl)-3,3-difluoropiperidine; (3,3-Difluoro-5-(aminomethyl)piperidin-1-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Aminomethyl)-3,3-difluoropiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (nitrogen or argon) when possible to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.