Description

(11As)-1,2,10,11-Tetramethyl-4,8-Bis(T-Butyl)-6-[[(2S,5S)-(2,5-Diphenyl-1-Phospholanyl) Methoxy]-Dibenzo[D,F][1,3,2]Dioxaphosphepin] Saxs,S-Bobphos CAS NO 1373349-83-7 is a sophisticated, chiral phosphine-oxazoline hybrid ligand designed for asymmetric catalysis. This compound matters because it provides exceptional stereoselectivity and high activity in transition metal-catalyzed reactions, enabling the synthesis of complex chiral molecules with high enantiomeric purity. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical intermediates.
• Cross-Coupling Reactions: Enhances efficiency and selectivity in asymmetric Suzuki-Miyaura, Heck, and related C-C bond-forming reactions.
• Hydrofunctionalization: Catalyzes the asymmetric addition of boranes, silanes, and other reagents across unsaturated bonds.
• Pharmaceutical Intermediate Synthesis: Key for constructing chiral centers in drug candidates for oncology, CNS disorders, and cardiovascular diseases.
• Agrochemical Active Ingredient Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new asymmetric transformations in process chemistry.

Basic Information

Product Name	(11As)-1,2,10,11-Tetramethyl-4,8-Bis(T-Butyl)-6-[[(2S,5S)-(2,5-Diphenyl-1-Phospholanyl) Methoxy]-Dibenzo[D,F][1,3,2]Dioxaphosphepin] Saxs,S-Bobphos
CAS No.	1373349-83-7
Molecular Formula	C46H52O3P2
Molecular Weight	714.85 g/mol
Synonyms	Saxs,S-Bobphos; Saxs-S-Bobphos; (S,S)-Saxs-Bobphos; Saxs-Bobphos Ligand; (S,S)-Saxs,S-Bobphos; Bobphos Saxs,S-; 1,2,10,11-Tetramethyl-4,8-di-tert-butyl-6-{[(2S,5S)-2,5-diphenylphospholan-1-yl]methoxy}dibenzo[d,f][1,3,2]dioxaphosphepine
EINECS	Contact for details

Quality Control

Every batch of Saxs,S-Bobphos is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity. Our standard quality commitment includes comprehensive characterization by NMR, HPLC, and chiral analysis to confirm identity, assay, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.