Description

2A€-Dihydro Boceprevir-D9 (Boceprevir Metabolite M28-D9+M31-D9 (Mixture Of Diastereomers)) is a deuterated internal standard critical for the precise quantification of boceprevir metabolites in complex biological matrices. This high-purity compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies in pharmaceutical research and development. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development and validation for antiviral drug candidates.

Application

• Bioanalytical Reference Standard: Serves as a deuterium-labeled internal standard for the accurate quantification of Boceprevir metabolites M28 and M31 in plasma, serum, and other biological fluids using LC-MS/MS.
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug metabolite concentration over time, crucial for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Metabolite Profiling & Identification: Used in mass spectrometry-based assays to identify and characterize the metabolic pathways of Boceprevir, aiding in drug safety assessments.
• Method Development & Validation: A key component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions to agencies like the FDA and EMA.
• Doping Control & Forensic Analysis: Can be employed in specialized testing protocols where precise differentiation and quantification of specific drug metabolites are required.

Basic Information

Product Name	2A€-Dihydro Boceprevir-D9 (Boceprevir Metabolite M28-D9+M31-D9 (Mixture Of Diastereomers))
CAS No.	1373318-85-4
Molecular Formula	C₂₇H₃₆D₉N₅O₅
Molecular Weight	Approx. 525.7 g/mol
Synonyms	Boceprevir Metabolite M28-D9; Boceprevir Metabolite M31-D9; (1R,2S,5S)-N-[(1S)-3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[(1,1-Dimethylethyl)amino]carbonyl]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide-D9; Deuterated Boceprevir Dihydroxy Metabolite; Boceprevir-d9 Metabolite; Internal Standard for Boceprevir LC-MS/MS
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality protocols to ensure exceptional isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and mass spectrometry. Our quality system is designed to support GLP and research-grade applications, ensuring data traceability and reliability for critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content, MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	<1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.