Description

m-Peg8-Succinimidyl Carbonate is a heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive N-hydroxysuccinimide (NHS) ester group. This compound is critical for creating stable amide bonds between PEG chains and primary amines, a foundational technique in bioconjugation and polymer chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for drug delivery system development, protein PEGylation, and surface functionalization.

Application

• Pharmaceutical PEGylation: Conjugation to therapeutic peptides, proteins, and antibodies to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Drug Delivery System Fabrication: Functionalization of liposomes, nanoparticles, and micelles to create stealth carriers with improved targeting and pharmacokinetic profiles.
• Bioconjugation & Crosslinking: A key reagent for linking PEG spacers to amine-containing molecules, such as enzymes, dyes, or small molecule drugs, in diagnostic and research applications.
• Surface Modification: Grafting of hydrophilic, non-fouling PEG layers onto medical devices, biosensors, and implant surfaces to prevent protein adsorption and biofouling.
• Hydrogel & Biomaterial Synthesis: Incorporation as a crosslinker or functional component in the development of biocompatible hydrogels for tissue engineering and controlled release matrices.
• Linker for ADC Development: Serving as a component in the construction of cleavable or non-cleavable linkers for Antibody-Drug Conjugates (ADCs).

Basic Information

Product Name	m-Peg8-Succinidyl Carbonate
CAS No.	1372860-04-2
Molecular Formula	C28H51NO15
Molecular Weight	641.71 g/mol
Synonyms	mPEG8-SC; m-PEG8-NHS Ester; Methoxy-PEG8-succinimidyl carbonate; 8-Arm PEG-SC; α-Methoxy-ω-succinimidyl carboxy polyethylene glycol (n=8); PEG8 Methyl Ether Succinimidyl Carbonate; Succinimidyl Carbonate Methoxy PEG8; SC-PEG8-OMe
EINECS	Contact for details

Quality Control

Our m-Peg8-Succinimidyl Carbonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the active NHS ester is susceptible to hydrolysis. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Substitution	> 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.