Description

1-Fluoro-3-Isopropoxy-5-Methylbenzene is a high-purity fluorinated aromatic ether building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where its unique substitution pattern enables precise molecular design. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce fluorine and alkoxy functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine and alkoxy side chains into polymer backbones, altering thermal and solubility properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination and etherification pathways in academic and industrial labs.

Basic Information

Product Name	1-Fluoro-3-Isopropoxy-5-Methylbenzene
CAS No.	1369853-40-6
Molecular Formula	C10H13FO
Molecular Weight	168.21 g/mol
Synonyms	3-Fluoro-5-methylphenyl isopropyl ether; 5-Methyl-3-fluorophenyl isopropyl ether; 1-Fluoro-3-(1-methylethoxy)-5-methylbenzene; 3-Isopropoxy-5-methylfluorobenzene; Isopropyl 3-fluoro-5-methylphenyl ether; m-Fluoro-m-methylphenyl isopropyl ether
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-Isopropoxy-5-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.