Description

2-Pyrrolidinepropanoic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-β-Methoxy-α-Methyl-, (αr,βr,2S)-, Compd. With n-Cyclohexylcyclohexanamine (1:1) is a high-purity, non-racemic chiral building block and salt form of a complex amino acid derivative. This compound is specifically engineered for advanced pharmaceutical synthesis and research, offering a defined stereochemistry critical for developing active pharmaceutical ingredients (APIs) with high enantiomeric purity. It is an essential intermediate for medicinal chemists and process development scientists working in asymmetric synthesis, peptide mimetics, and drug discovery programs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents and APIs.
• Asymmetric Catalysis Research: Used as a ligand precursor or a substrate in the development and study of stereoselective chemical transformations.
• Peptidomimetic Design: Serves as a constrained, non-proteinogenic amino acid analog for creating stable peptide-like molecules with enhanced pharmacological properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of chiral drugs.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Academic & Institutional Research: A valuable tool for investigating reaction mechanisms and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Item	Details
Product Name	2-Pyrrolidinepropanoic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-β-Methoxy-α-Methyl-, (αr,βr,2S)-, Compd. With n-Cyclohexylcyclohexanamine (1:1)
CAS No.	1369427-40-6
Molecular Formula	C15H27NO5 • C12H23N
Molecular Weight	Contact for details
Synonyms	(2S,αR,βR)-1-(tert-Butoxycarbonyl)-α-methyl-β-methoxy-2-pyrrolidinepropanoic Acid Compound with Dicyclohexylamine (1:1); Boc-β-methoxy-α-methyl-L-proline DCHA Salt; (αR,βR,2S)-1-[(tert-Butoxycarbonyl)]-β-methoxy-α-methylproline Dicyclohexylamine Salt; tert-Butyl (2S,αR,βR)-α-methyl-β-methoxy-1,2-pyrrolidinedicarboxylate DCHA Salt; Chiral Proline Derivative DCHA Salt; Non-Racemic Amino Acid Derivative Salt; Pharmaceutical Building Block Salt; CAS 1369427-40-6
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Each lot is characterized using advanced analytical techniques including HPLC, chiral chromatography, and NMR to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.