Description

T-Boc-n-Amido-Peg2-Acid CAS NO 1365655-91-9 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butoxycarbonyl (Boc)-protected amine and a carboxylic acid terminus. This compound is essential for creating stable, cleavable, and hydrophilic spacers in bioconjugation and drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and functionalized nanoparticles.

Application

• Key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Functional spacer for peptide and protein modification, enhancing solubility and stability.
• Intermediate in the development of PEGylated drug delivery systems and prodrugs.
• Crosslinking agent for the surface functionalization of nanoparticles and biomaterials.
• Critical reagent in proteolysis-targeting chimera (PROTAC) and linker chemistry.
• Used in diagnostic assay development and biosensor fabrication.
• Intermediate for solid-phase peptide synthesis (SPPS) and combinatorial chemistry.

Basic Information

Product Name	T-Boc-n-Amido-Peg2-Acid
CAS No.	1365655-91-9
Molecular Formula	C₁₄H₂₇NO₇
Molecular Weight	321.37 g/mol
Synonyms	2-[2-[2-(tert-Butoxycarbonylamino)ethoxy]ethoxy]acetic Acid; Boc-NH-PEG2-CH2COOH; tert-Butyl N-[2-[2-(carboxymethoxy)ethoxy]ethyl]carbamate; 2,2'-(Ethylenedioxy)diacetic Acid 2-(Boc-amino)ethyl Ester; Boc-Amino-PEG2-Acid; T-Boc-8-amino-3,6-dioxaoctanoic Acid; (Boc-NH-PEG2-COOH); PEG2 Acid Boc Amide
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.