Description

Chloroacetamido-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative designed for advanced bioconjugation and linker chemistry. This compound matters for its role as a key intermediate in the synthesis of antibody-drug conjugates (ADCs), peptide therapeutics, and other targeted drug delivery systems, offering a reactive chloroacetyl group and a protected terminal acid. It is primarily needed by pharmaceutical R&D teams, biotech companies, and CROs specializing in the development of next-generation biologics and precision medicines.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a critical building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide & Protein Modification: Used to introduce functional handles (e.g., for subsequent click chemistry) onto peptides, proteins, and other biomolecules via reaction with free thiol or amine groups.
• Polymer-Assisted Drug Delivery: Acts as a functional monomer or cross-linker in the development of PEGylated drug carriers, micelles, and nanoparticles to enhance solubility and pharmacokinetics.
• Diagnostic Probe Conjugation: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting molecules for in vitro and in vivo diagnostics.
• Surface Functionalization: Enables the modification of biosensor surfaces, microarray chips, and other solid supports with bioactive molecules for assay development.
• Research Grade Chemical Biology: Provides a versatile tool for academic and industrial researchers exploring novel bioconjugation strategies and prodrug activation mechanisms.

Basic Information

Product Name	Chloroacetamido-Peg4-T-Butyl Ester
CAS No.	1365655-90-8
Molecular Formula	C19H36ClNO8
Molecular Weight	441.95 g/mol
Synonyms	2-Chloro-N-(17-tert-butoxy-3,6,9,12,15-pentaoxa-16-azaheptadecan-1-yl)acetamide; Chloroacetamido-PEG4-t-butyl ester; t-Butyl-PEG4-chloroacetamide; N-(17-(tert-Butoxy)-3,6,9,12,15-pentaoxa-16-azaheptadecyl)-2-chloroacetamide; 2-Chloro-N-[17-(2-methyl-2-propanyloxy)-3,6,9,12,15-pentaoxa-16-azaheptadecyl]acetamide; tert-Butyl 17-((2-chloroacetamido)methyl)-3,6,9,12,15-pentaoxa-17-azaheptadecanoate; Chloroacetyl-PEG4-t-butyl ester; Amino-PEG4-t-butyl ester chloroacetamide
EINECS	Contact for details

Quality Control

Our Chloroacetamido-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.