Description

(S)-2,2'-Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl is a highly specialized, chiral phosphine ligand designed for advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for synthesizing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Synthesis: Facilitates the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric C-C and C-X bond-forming reactions for high-value fragrance, flavor, and electronic chemical intermediates.
• Academic & Industrial R&D: A critical tool for developing new catalytic methodologies and exploring novel synthetic pathways in process chemistry.
• Catalyst Library Development: Serves as a premium component in screening libraries for identifying optimal catalytic systems for specific transformations.

Basic Information

Product Name	(S)-2,2'-Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl
CAS No.	1365531-99-2
Molecular Formula	C72H100O12P2
Molecular Weight	1187.50 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-DTBM-SEGPHOS Ligand; (S)-2,2'-Bis(di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; SEGPHOS-DTBM; (S)-DTBM-SEGPHOS (CAS 1365531-99-2); (S)-Bisphosphine Ligand DTBM-SEGPHOS
EINECS	Contact for details

Quality Control

Every batch of our (S)-DTBM-SEGPHOS ligand is produced and tested under strict quality management systems to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and key impurity profiles. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.