Description

(R)-2,2'-Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl, 97+% is a high-purity, chiral bisphosphine ligand of significant importance in asymmetric catalysis. This compound is valued for its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer intermediates. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of chiral active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical synthesis.
• Catalyst component for enantioselective C-C bond formation (e.g., cross-coupling, allylic substitution).
• Key reagent in the research and development of single-enantiomer drug candidates and agrochemicals.
• Used in academic and industrial R&D to explore new catalytic methodologies.
• Production of chiral intermediates for flavors, fragrances, and advanced materials.
• As a reference standard for analytical method development and quality control in chiral chemistry.

Basic Information

Product Name	(R)-2,2'-Bis[Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl, 97+%
CAS No.	1365531-98-1
Molecular Formula	C72H100O8P2
Molecular Weight	1139.48 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-DTBM-Segphos; (R)-2,2'-Bis(di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (R)-DTBM-SEGPHOS Ligand; (R)-SEGPHOS derivative; SEGPHOS-DTBM (R); Chiral bisphosphine ligand DTBM-SEGPHOS
EINECS	Contact for details

Quality Control

Our (R)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by NMR, HPLC, and optical rotation analysis to confirm identity, chemical purity (≥97%), and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97%
Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.