Description

(R)-2,2'-Bis[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl is a sophisticated, chiral bisphosphine ligand of significant importance in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, amines, and alcohols.
• Catalyst component for asymmetric C-C bond-forming reactions, including cross-coupling and allylic substitution.
• Key reagent in the development and scale-up of novel pharmaceutical intermediates requiring high optical purity.
• Use in academic and industrial research for exploring new catalytic methodologies in organic synthesis.
• Potential application in the synthesis of chiral agrochemicals and flavors & fragrances.

Basic Information

Product Name	(R)-2,2'-Bis[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl
CAS No.	1365531-93-6
Molecular Formula	C56H68O8P2
Molecular Weight	931.08 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-DTBM-SEGPHOS Ligand; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (R)-DTBM-SEGPHOS (alternative notation); SEGPHOS derivative with DTBM substituents; Chiral DTBM-SEGPHOS ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized to confirm identity, purity, and chiral integrity, supported by a comprehensive Certificate of Analysis (COA). We adhere to strict quality management protocols to ensure batch-to-batch consistency, which is critical for reproducible catalytic performance in sensitive asymmetric syntheses. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.