Description

(S)-2,2'-Bis[Bis(3,5-Dimethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl is a high-value, chiral bisphosphine ligand crucial for enabling highly selective asymmetric catalytic transformations. Its significance lies in its ability to impart exceptional enantioselectivity and activity in transition metal-catalyzed reactions, directly impacting the efficiency and cost-effectiveness of producing complex chiral molecules. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for synthesizing active pharmaceutical ingredients (APIs) and other advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, a key step in API manufacturing.
• Asymmetric C-C Bond Formation: Critical for cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution reactions to construct chiral carbon frameworks with high fidelity.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates for therapeutic areas such as oncology, CNS disorders, and metabolic diseases.
• Agrochemical Active Ingredient Production: Used in the synthesis of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Process Chemistry & Scale-up: Provides robust performance for transitioning from laboratory-scale discovery to pilot and commercial-scale production.
• Catalyst Screening & Development: A valuable tool for chemists in high-throughput screening and developing new catalytic methodologies.
• Academic & Industrial Research: Serves as a benchmark ligand in studies exploring new asymmetric reactions and mechanistic investigations.

Basic Information

Product Name	(S)-2,2'-Bis[Bis(3,5-Dimethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl
CAS No.	1365531-90-3
Molecular Formula	C52H56O4P2
Molecular Weight	806.93 g/mol
Synonyms	(S)-DTMB; (S)-DTMB-BIPHEP; (S)-2,2'-Bis(di-3,5-xylylphosphino)-4,4',6,6'-tetramethoxybiphenyl; (S)-4,4',6,6'-Tetramethoxy-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]biphenyl; (S)-DTMB-BIPHEP Ligand; (S)-DTMB-BIPHEP; (S)-DTMB-BIPHEP; (S)-DTMB-BIPHEP
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under stringent quality management systems to ensure exceptional purity and batch-to-batch consistency, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and key impurity profiles. Our quality commitment aligns with the standards required for cGMP-compliant pharmaceutical development and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.