Description

(S)-2,2'-Bis[Bis(3,5-Trifluoromethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl is a highly specialized, chiral bisphosphine ligand crucial for enabling precise asymmetric synthesis. Its value lies in its ability to induce exceptional enantioselectivity in transition metal-catalyzed reactions, directly impacting the efficiency and purity of advanced chemical manufacturing. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance catalysts for producing chiral intermediates and active ingredients.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component for enantioselective C-C bond formation (e.g., cross-coupling, allylic substitution).
• Critical for the production of single-enantiomer active pharmaceutical ingredients (APIs) in drug development.
• Use in the synthesis of chiral agrochemicals and specialty fine chemicals.
• Research and development of novel homogeneous catalytic processes in academia and industry.
• Process optimization and scale-up for cost-effective manufacturing of high-value chiral compounds.

Basic Information

Product Name	(S)-2,2'-Bis[Bis(3,5-Trifluoromethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl
CAS No.	1365531-85-6
Molecular Formula	C48H32F12O4P2
Molecular Weight	938.70 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-Bis[3,5-bis(trifluoromethyl)phenyl]-4,4',6,6'-tetramethoxy-2,2'-biphenyldiylphosphine; (S)-DTBM-SEGPHOS Ligand; (S)-5,5'-Bis[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-4,4'-bi-1,3-benzodioxole; (S)-4,4'-Bi-1,3-benzodioxole-5,5'-diylbis[bis[3,5-bis(trifluoromethyl)phenyl]phosphine]; SEGPHOS-DTBM; (S)-DTBM-SEGPHOS (CAS 1365531-85-6)
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity (enantiomeric excess) verification and quantitative assay. Certificates of Analysis (COA) detailing all specifications are provided to support your quality management systems and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Handle and package the product in a glovebox or under a continuous inert gas purge to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Moisture (KF Titration)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.