Description

(R)-2,2'-Bis[Bis(3,5-Trifluoromethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl, 97+% is a high-purity, chiral bisphosphine ligand essential for advanced asymmetric catalysis. This compound matters because it enables highly selective and efficient transition-metal-catalyzed reactions, which are critical for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require robust and selective ligands for challenging synthetic transformations.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing complex, single-enantiomer active pharmaceutical ingredients (APIs) with high optical purity.
• Cross-Coupling Reactions: Used in asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions.
• Agrochemical Manufacturing: Enables the production of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Fine Chemical Production: Applied in the synthesis of high-value chiral flavors, fragrances, and advanced materials.

Basic Information

Product Name	(R)-2,2'-Bis[Bis(3,5-Trifluoromethylphenyl)Phosphino]-4,4',6,6'-Tetramethoxybiphenyl, 97+%
CAS No.	1365531-84-5
Molecular Formula	C48H32F24O4P2
Molecular Weight	1190.70 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-3,5-(CF3)2-SEGPHOS; (R)-Bis[3,5-bis(trifluoromethyl)phenyl]-SEGPHOS; (R)-2,2'-Bis[bis(3,5-bis(trifluoromethyl)phenyl]phosphino]-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (R)-DTBM-SEGPHOS Ligand; (R)-5,5'-Bis[bis(3,5-bis(trifluoromethyl)phenyl]phosphino]-4,4'-bi-1,3-benzodioxole; SEGPHOS derivative with 3,5-(CF3)2C6H3 groups.
EINECS	Contact for details

Quality Control

Our (R)-DTBM-SEGPHOS is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC and 31P NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.