Description

(S)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl CAS NO 1365531-82-3 is a highly specialized, chiral bisphosphine ligand designed for asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical API synthesis.
• Catalyst component for enantioselective C-C and C-X bond-forming cross-coupling reactions.
• Key reagent in the development of stereochemically pure agrochemicals and flavors/fragrances.
• Use in academic and industrial research for method development in asymmetric synthesis.
• Potential application in materials science for creating chiral polymers or surfaces.

Basic Information

Product Name	(S)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl
CAS No.	1365531-82-3
Molecular Formula	C46H48O4P2
Molecular Weight	726.81 g/mol
Synonyms	(S)-DTMB; (S)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (S)-DTMB-Biphenyl; (S)-DTMB-Phos; (S)-Bis(di-p-tolylphosphino)tetramethoxybiphenyl; (S)-4,4',6,6'-Tetramethoxy-2,2'-bis(di-p-tolylphosphino)-1,1'-biphenyl; Chiral DTMB Ligand; (S)-Biphenyl-2,2'-diylbis(di-p-tolylphosphine) tetramethoxy derivative
EINECS	Contact for details

Quality Control

Our (S)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for catalyst ligands in regulated industries. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and performance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.