Description

(R)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl CAS NO 1365531-81-2 is a high-purity, chiral bisphosphine ligand essential for advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This product is specifically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates chiral induction in palladium-catalyzed cross-coupling processes for constructing complex, optically active molecules.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for manufacturing chiral intermediates for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric catalytic cycles in research laboratories.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Item	Details
Product Name	(R)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl
CAS No.	1365531-81-2
Molecular Formula	C46H48O4P2
Molecular Weight	726.81 g/mol
Synonyms	(R)-DTMB; (R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (R)-4,4',6,6'-Tetramethoxy-2,2'-bis(di-p-tolylphosphino)-1,1'-biphenyl; (R)-DTMB-BIPHEP; (R)-Bisphosphine Ligand DTMB; (R)-DTMB-Biphenyl Phosphine; (R)-Chiral DTMB Ligand; (R)-Tetramethoxy Biphenyl Bisphosphine
EINECS	Contact for details

Quality Control

Every batch of our (R)-2,2'-Bis(Di-p-Tolylphosphino)-4,4',6,6'-Tetramethoxy)-1,1'-Biphenyl undergoes rigorous analytical testing to ensure it meets the stringent purity standards required for asymmetric synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and metal content. Our quality management system is designed to support cGMP and ISO guidelines for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Palladium (Pd) Content	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.