Description

(S)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in API synthesis.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including those for cardiovascular and central nervous system therapies.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(S)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl
CAS No.	1365531-76-5
Molecular Formula	C44H40O4P2
Molecular Weight	694.73 g/mol
Synonyms	(S)-DTMBP; (S)-4,4',6,6'-Tetramethoxy-2,2'-bis(diphenylphosphino)biphenyl; (S)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (S)-DTMBP Ligand; (S)-Biphenyl-2,2'-diyl)bis(diphenylphosphine) tetramethoxy derivative; (S)-Tetramethoxy-BIPHEP analog; (S)-DTMBiphep; Chiral DTMBP
EINECS	Contact for details

Quality Control

Every batch of (S)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl is manufactured and tested under strict quality management systems. We guarantee high chemical and enantiomeric purity, with comprehensive analysis via HPLC, NMR, and chiral chromatography. A Certificate of Analysis (COA) detailing identity, purity, and specific rotation is provided with each shipment to ensure compliance with your R&D and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.