Description

(R)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates palladium-catalyzed C-C and C-X bond-forming reactions with high enantioselectivity.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the commercial-scale production of specialty flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	(R)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl
CAS No.	1365531-75-4
Molecular Formula	C40H36O4P2
Molecular Weight	642.66 g/mol
Synonyms	(R)-DTMB; (R)-2,2'-Bis(diphenylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl; (R)-4,4',6,6'-Tetramethoxy-2,2'-bis(diphenylphosphino)biphenyl; (R)-DTMBiphep; (R)-DTM-BIPHEP; (R)-Bisphosphine Ligand DTMB; (R)-DTM-BIPHEP Ligand; (R)-DTMB-BIPHEP
EINECS	Contact for details

Quality Control

Our (R)-2,2'-Bis(Diphenylphosphino)-4,4',6,6'-Tetramethoxybiphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and ICP-MS for trace metal analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure compliance with your research and process development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Trace Metals (ICP-MS)	≤100 ppm total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.