Description

2-Bromo-6-Thiomorpholinobenzonitrile is a high-value, multi-functional chemical intermediate featuring a bromine substituent and a thiomorpholine ring system. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering a strategic handle for cross-coupling and functional group interconversion. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic structure for bioactivity.
• Material Science: Serves as a precursor for organic electronic materials and liquid crystals due to its conjugated aromatic system.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Heck, and Buchwald-Hartwig amination reactions.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific, complex aromatic architectures.

Basic Information

Product Name	2-Bromo-6-Thiomorpholinobenzonitrile
CAS No.	1365272-93-0
Molecular Formula	C11H11BrN2S
Molecular Weight	283.19 g/mol
Synonyms	2-Bromo-6-(thiomorpholin-4-yl)benzonitrile; 6-Bromo-2-(thiomorpholino)benzonitrile; Benzonitrile, 2-bromo-6-(4-thiomorpholinyl)-; 2-(Thiomorpholino)-6-bromobenzonitrile; 4-(2-Cyano-3-bromophenyl)thiomorpholine; 1365272-93-0; CAS 1365272-93-0
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Thiomorpholinobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.