Description

3-(3-Fluoro-5-Methoxyphenyl)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both electron-withdrawing (nitrile) and electron-donating (methoxy) groups on a fluorinated biphenyl scaffold, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its unique substitution pattern can be leveraged to fine-tune biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine atom and aromatic nitrile group can enhance metabolic stability and target binding.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Modification: Employed in the synthesis of specialty polymers and resins, where incorporation can alter thermal stability, solubility, and optical characteristics.
• Chemical Research & Development: A valuable reagent for method development in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and for studying structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	3-(3-Fluoro-5-Methoxyphenyl)Benzonitrile
CAS No.	1365272-73-6
Molecular Formula	C14H10FNO
Molecular Weight	227.24 g/mol
Synonyms	3'-Fluoro-5'-methoxy-[1,1'-biphenyl]-3-carbonitrile; [1,1'-Biphenyl]-3-carbonitrile, 3'-fluoro-5'-methoxy-; 3-(3-Fluoro-5-methoxyphenyl)benzonitrile; 3-Fluoro-5-methoxy-3'-cyanobiphenyl; 3-Cyano-3'-fluoro-5'-methoxybiphenyl
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Fluoro-5-Methoxyphenyl)Benzonitrile is produced and analyzed under strict quality management protocols to ensure consistency and high purity suitable for research and scale-up applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.