Description

4-(2-Cyanophenyl)-n-Ethyl-2-Fluorobenzamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzamide structure with cyano and fluoro substituents. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of enzyme inhibitors, given the benzamide pharmacophore.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitor candidates for oncology and inflammatory disease applications.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP manufacturing of novel therapeutic agents.

Basic Information

Product Name	4-(2-Cyanophenyl)-n-Ethyl-2-Fluorobenzamide
CAS No.	1365272-25-8
Molecular Formula	C16H13FN2O
Molecular Weight	268.29 g/mol
Synonyms	2-Fluoro-N-ethyl-4'-(2-cyanophenyl)benzamide; 4-(2-Cyanophenyl)-N-ethyl-2-fluorobenzamide; N-Ethyl-2-fluoro-4'-(2-cyanophenyl)benzamide; 2-Fluoro-4'-(2-cyanophenyl)-N-ethylbenzamide; Benzamide, 4-(2-cyanophenyl)-N-ethyl-2-fluoro-; 1365272-25-8
EINECS	Contact for details

Quality Control

Our 4-(2-Cyanophenyl)-n-Ethyl-2-Fluorobenzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.