Description

2-Bromo-6-Ethoxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromine and nitrile functional groups on an ethoxy-substituted benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the bromine atom serves as a handle for further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its rigid, substituted aromatic core.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nitrile Transformation Chemistry: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles and triazoles.

Basic Information

Product Name	2-Bromo-6-Ethoxybenzonitrile
CAS No.	1365271-92-6
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	6-Bromo-2-ethoxybenzonitrile; 2-Ethoxy-6-bromobenzonitrile; Benzonitrile, 2-bromo-6-ethoxy-; 2-Bromo-6-ethoxybenzenecarbonitrile; (2-Bromo-6-ethoxyphenyl)cyanide; 6-Bromo-o-ethoxybenzonitrile; 2-Bromo-6-ethoxy-phenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Ethoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.