Description

4-[(3-Fluorophenyl)Carbonyl]Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this precise chemical scaffold to introduce both fluorophenyl and benzonitrile functionalities into target structures, enabling the fine-tuning of biological activity and material properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorine atom enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal molecules and electron-transport materials in organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating high-performance, specialty polymers with enhanced thermal and chemical resistance.
• Chemical Synthesis Reagent: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano-group transformations.
• Material Science Research: Investigated for use in metal-organic frameworks (MOFs) and as a ligand precursor in coordination chemistry.

Basic Information

Item	Detail
Product Name	4-[(3-Fluorophenyl)Carbonyl]Benzonitrile
CAS No.	1365271-67-5
Molecular Formula	C14H8FNO
Molecular Weight	225.22 g/mol
Synonyms	4-(3-Fluorobenzoyl)benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 3'-fluoro-; 3-Fluoro-4'-cyanobenzophenone; 4-Cyanophenyl 3-fluorophenyl ketone; 3-Fluorobenzophenone-4'-carbonitrile; 4-(3-Fluorobenzoyl)benzonitrile; 3'-Fluoro-4-cyanobenzophenone; 4-Benzoylbenzonitrile, 3'-fluoro- derivative
EINECS	Contact for details

Quality Control

Our 4-[(3-Fluorophenyl)Carbonyl]Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.