Description

4-(Benzyloxy)-2-Bromo-1-Fluorobenzene is a high-purity fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionalization, providing distinct reactive sites for sequential cross-coupling and substitution reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as active pharmaceutical ingredients (APIs) and specialty chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated and brominated aromatic cores for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides where the benzyloxy, bromo, and fluoro substituents impart specific biological activity.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille), while the fluorine and benzyloxy groups offer sites for further functionalization.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling in related chemical processes.

Basic Information

Product Name	4-(Benzyloxy)-2-Bromo-1-Fluorobenzene
CAS No.	1364572-05-3
Molecular Formula	C₁₃H₁₀BrFO
Molecular Weight	281.12 g/mol
Synonyms	2-Bromo-4-(benzyloxy)-1-fluorobenzene; 1-Fluoro-2-bromo-4-(phenylmethoxy)benzene; 4-Benzyloxy-2-bromofluorobenzene; 2-Bromo-1-fluoro-4-(phenylmethoxy)benzene; Benzene, 2-bromo-1-fluoro-4-(phenylmethoxy)-; 1364572-05-3; 4-(Benzyloxy)-2-bromofluorobenzene
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-2-Bromo-1-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.