Description

1-Amino-3-Fluorocyclobutane-1-Methanol is a versatile and high-value fluorinated cyclobutane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both amino and fluorinated alcohol functionalities on a strained cyclobutane ring, makes it an essential intermediate for constructing complex molecules with precise stereochemistry. This compound is particularly valuable for pharmaceutical R&D and fine chemical manufacturing, where it is used to develop novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and rigid cyclobutane core can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal and chemical resistance properties.
• Peptidomimetics & Bioisosteres: The fluorinated cyclobutane moiety is used to replace traditional peptide bonds or aromatic rings, improving metabolic stability and binding affinity in drug design.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	1-Amino-3-Fluorocyclobutane-1-Methanol
CAS No.	1363383-42-9
Molecular Formula	C5H10FNO
Molecular Weight	119.14 g/mol
Synonyms	(1-Amino-3-fluorocyclobutyl)methanol; 3-Fluoro-1-(hydroxymethyl)cyclobutanamine; 1-(Aminomethyl)-3-fluorocyclobutanol; 1-Fluoro-3-(hydroxymethyl)cyclobutanamine; FCB-AM Alcohol; Fluorocyclobutane Amino Alcohol; 1363383-42-9
EINECS	Contact for details

Quality Control

Our 1-Amino-3-Fluorocyclobutane-1-Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.