Description

1-Boc-4-Ethynyl-4-Methylpiperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with an ethynyl functional handle. This compound is critical for medicinal chemists as it enables the efficient synthesis of complex molecules through versatile click chemistry and cross-coupling reactions. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in oncology and CNS therapeutic areas.
• Click Chemistry Reagent: Utilized in Huisgen cycloaddition and other bioorthogonal reactions for labeling, bioconjugation, and polymer synthesis.
• Ligand & Catalyst Development: Serves as a precursor for creating novel ligands and organometallic catalysts used in asymmetric synthesis.
• Agrochemical Research: Intermediate in the development of new pesticides and herbicides with novel modes of action.
• Material Science: Used in the creation of specialty polymers and functional materials requiring precise molecular architecture.
• Chemical Biology Probes: Enables the synthesis of molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	1-Boc-4-Ethynyl-4-Methylpiperidine
CAS No.	1363383-17-8
Molecular Formula	C13H21NO2
Molecular Weight	223.31 g/mol
Synonyms	tert-Butyl 4-ethynyl-4-methylpiperidine-1-carboxylate; 4-Ethynyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-ethynyl-4-methylpiperidine; 1-(tert-Butoxycarbonyl)-4-ethynyl-4-methylpiperidine; N-Boc-4-ethynyl-4-methylpiperidine; 4-Methyl-4-ethynylpiperidine-1-carboxylic acid tert-butyl ester; 1363383-17-8; BEMP
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Ethynyl-4-Methylpiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.