Description

Cyclobutanecarboxylic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (1S,2S)- is a high-purity, stereochemically defined Fmoc-protected amino acid derivative, essential for advanced peptide synthesis. This compound matters because it provides a critical, conformationally constrained building block for developing novel therapeutic peptides and peptidomimetics with enhanced metabolic stability and target selectivity. It is primarily needed by pharmaceutical R&D teams, CROs, and CDMOs engaged in the discovery and development of peptide-based drugs, hormone analogs, and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: Incorporation of the rigid cyclobutane ring to mimic peptide secondary structures and improve drug-like properties.
• Pharmaceutical Intermediate: Serving as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for metabolic and oncological targets.
• Research & Development: Used in academic and industrial labs for studying structure-activity relationships (SAR) and developing new bioactive compounds.
• Combinatorial Chemistry: A valuable building block in libraries designed for high-throughput screening against novel biological targets.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (1S,2S)-
CAS No.	1363333-51-0
Molecular Formula	C20H19NO4
Molecular Weight	337.37 g/mol
Synonyms	(1S,2S)-2-[(Fmoc-amino)cyclobutanecarboxylic acid; Fmoc-(1S,2S)-ACBC-OH; Fmoc-(1S,2S)-2-aminocyclobutanecarboxylic acid; (1S,2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclobutanecarboxylic acid; (1S,2S)-ACBC(Fmoc); Fmoc-ACBC((1S,2S))-OH; 2-(Fmoc-amino)cyclobutanecarboxylic acid (1S,2S)-isomer; Fmoc-(1S,2S)-2-Acbc
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (1S,2S)- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (1S,2S)-isomer
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.