Description

Serpinin (Mouse, Rat), Chromogranin-A (417-442) (Mouse) is a synthetic peptide fragment corresponding to the 417-442 sequence of mouse Chromogranin-A, which is a key precursor protein for bioactive peptides. This specific sequence is crucial for research into the serpinin peptide family, which plays significant roles in neuroendocrine regulation and cardiovascular function. It is an essential biochemical tool for academic and pharmaceutical researchers studying chromogranin-derived peptides, their processing, and their physiological effects in rodent models.

Application

• Neuroscience Research: Investigation of the role of serpinin peptides in neuroendocrine signaling, neuroprotection, and neurotransmitter regulation.
• Cardiovascular Studies: Research into the cardiovascular effects of chromogranin-A derived peptides, including their influence on heart function and blood pressure.
• Biomarker Development: Used as a reference standard in immunoassays (ELISA, RIA) to detect and quantify endogenous serpinin levels in biological samples.
• Peptide Structure-Activity Relationship (SAR) Studies: Serves as a core sequence for designing analogs to understand the pharmacophore and optimize biological activity.
• Cell Biology & Signal Transduction: Exploration of intracellular pathways activated by serpinin binding to its putative receptors.
• Pharmaceutical R&D: Preclinical evaluation of serpinin's therapeutic potential for conditions like heart failure, neurodegenerative diseases, and endocrine disorders.

Basic Information

Product Name	Serpinin (Mouse, Rat), Chromogranin-A (417-442) (Mouse)
CAS No.	1363332-88-0
Molecular Formula	C124H197N39O36S
Molecular Weight	2777.2 g/mol
Synonyms	Mouse Serpinin; Chromogranin A (417-442) mouse; CgA (417-442) (mouse); pGlu-Serpinin(1-26); Serpinin peptide; Chromogranin-A-derived peptide; CGA 417-442; Neuroendocrine peptide fragment
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of Serpinin (Mouse, Rat), Chromogranin-A (417-442) (Mouse) undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, MS, and amino acid analysis are provided to guarantee the material meets your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder under an inert atmosphere. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ± 10% of theoretical values
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.