Description

Fmoc-n-Methyl-Dl-Alanine CAS NO 1362858-88-5 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. Its core value lies in providing a sterically hindered, N-methylated alanine building block, enabling the creation of peptides with enhanced metabolic stability and modified conformational properties. This compound is critically needed by research institutions and pharmaceutical developers working on novel therapeutic peptides, peptidomimetics, and bioactive compounds where backbone modification is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the introduction of N-methylated amino acid residues into peptide chains, a common strategy to improve bioavailability and proteolytic stability.
• Peptidomimetic Drug Discovery: Used in the research and development of peptide-based therapeutics where conformational restriction and resistance to enzymatic degradation are desired.
• Combinatorial Chemistry Libraries: Employed to create diverse libraries of modified peptides for high-throughput screening against biological targets.
• Academic & Industrial Research: Serves as a crucial reagent for studying structure-activity relationships (SAR) in peptide science and medicinal chemistry.
• Synthesis of Conformationally Constrained Peptides: Facilitates the production of cyclic peptides or peptides with specific turn-inducing motifs due to the steric influence of the N-methyl group.
• Intermediate for Advanced Protecting Groups: Can be used in multi-step synthetic routes for more complex, orthogonally protected amino acid derivatives.

Basic Information

Product Name	Fmoc-n-Methyl-Dl-Alanine
CAS No.	1362858-88-5
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-N-Me-DL-Ala-OH; Fmoc-N-Methyl-DL-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-DL-alanine; N-Fmoc-N-methyl-DL-alanine; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]propanoic acid; DL-Fmoc-N-methylalanine; N-Methyl-N-Fmoc-DL-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-Dl-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.