Description

Oxazole, 4-(1,1-Dimethylethyl)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-5,5-Diphenyl-, (4S)- is a high-value, chiral organophosphorus ligand with a complex oxazoline backbone, designed for advanced asymmetric catalysis. This compound matters because it provides exceptional stereocontrol and tunable electronic properties, enabling the synthesis of complex chiral molecules with high enantiomeric purity. It is critically needed by research chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for developing novel synthetic routes and optimizing catalytic processes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high stereoselectivity.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers via allylic alkylation and amination reactions.
• Pharmaceutical Intermediate Manufacturing: Used in the production of active pharmaceutical ingredients (APIs) requiring specific chiral configurations.
• Agrochemical Synthesis: Applied in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic systems in asymmetric synthesis.
• Ligand Library Development: Serves as a sophisticated component in high-throughput screening libraries for catalyst discovery.

Basic Information

Product Name	Oxazole, 4-(1,1-Dimethylethyl)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-5,5-Diphenyl-, (4S)-
CAS No.	1362386-02-4
Molecular Formula	C41H38NOP
Molecular Weight	591.72 g/mol
Synonyms	(4S)-4-(tert-Butyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diphenyloxazole; (S)-t-Bu-PHOX; (S)-4-tert-Butyl-2-(2-diphenylphosphinophenyl)-4,5-dihydro-5,5-diphenyloxazole; (S)-2-[2-(Diphenylphosphino)phenyl]-4-(1,1-dimethylethyl)-4,5-dihydro-5,5-diphenyloxazole; PHOX Ligand (tert-Butyl variant); Chiral PHOX Ligand; Asymmetric Oxazoline-Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral ligand is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. Our standard quality protocol includes verification of chiral purity by chiral HPLC, assessment of chemical purity by NMR and HPLC, and confirmation of structure by spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results, including enantiomeric excess (ee), is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.